Figure 1. 

A 7-year-old spayed female Labrador Retriever presented for evaluation of multifocal to coalescing pustular, ulcerative, and crusting skin lesions affecting the trunk (Figure 1) and distal limbs (Figure 2). Some lesions exhibited a foul odor and extended into the subcutis. Skin biopsies were submitted for diagnostic evaluation. The dog had a documented history of pemphigus foliaceus diagnosed several months earlier and was managed by a dermatologist. Long term immunosuppressive therapy included oral prednisone and cyclosporine, with intermittent dose adjustments based on clinical response. The dog also had recurrent deep pyoderma caused by methicillin resistant Staphylococcus spp. and episodes of hepatopathy attributed to chronic medication use.

Figure 2. 

Figure 3. H&E, 40x magnification

Figure 4. H&E, 40x magnification

Figure 5. H&E, 40x magnification